Cardiac cells are stimulated by the movement of sodium, potassium, and calcium into and out of the cell via the ATP pump (Na

Human toxicity Digoxin is a very toxic compound, with an estimated lethal dose being only a few milligrams. Nausea and vomiting are early signs of acute digoxin toxicity. Among other symptoms are gastro-intestinal tract (GIT) disorders, abdominal pain, diarrhea, hyperkalemia, and muscle pain and weakness. Since digoxin is a cardiac medicine, its overdoses can have severe and multiple effects on the heart. Acute poisoning may result in sinus bradycardia, atrial and ventricular arrhythmias, and varying degrees of heart block, coma, and even death [1]. Acute exposure to digoxin can also have various neuropsychiatric effects, including drowsiness, weakness, and headache [1]. The therapeutic daily doses of digoxin are between 0.25 and 3 mg [2]. The minimum lethal dose is 10 mg/70 kg person [3]. The approximate therapeutic blood concentration is 0.001 mg/l [3]. The mean lethal serum concentration, based on the data from several handbooks, is 0.016 mg/l, and minimum lethal serum concentration is 0.0038 mg/l [4].